Hatzitolios Apostolos, Tzellos Thrasivoulos George, Savopoulos Christos, Tzalokostas Vasileios, Kaiafa Georgia, Psomas Evaggelos, Apostolopoulou Martha, Papadopoulos Athanasios
1st Medical Propedeutic Department, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
J Dermatol. 2008 May;35(5):297-300. doi: 10.1111/j.1346-8138.2008.00470.x.
We present a case of a 78-year-old man with erythema elevatum diutinum as a first clinical sign of non-Hodgkin's lymphoma. The patient developed erythema elevatum diutinum with an unusual distribution involving the trunk. Erythema elevatum diutinum is a rare dermatosis that is considered to be a localized, low-grade form of leukocytoclastic vasculitis associated with neoplastic, autoimmune and infectious processes. It is probably mediated by immune complexes. Recent studies report hematological disease as the most common factor associated with erythema elevatum diutinum. Many hematological diseases, such as myeloma, myelodysplastic syndrome and immunoglobulin (Ig)A monoclonal gammopathy, have been reported in association with erythema elevatum diutinum, but none with IgM monoclonal gammopathy and only one with malignant lymphoma. We would like to add IgM monoclonal gammopathy and non-Hodgkin's lymphoma as one of the diseases associated with erythema elevatum diutinum considering that the activity of erythema elevatum diutinum and non-Hodgkin's lymphoma fluctuated in parallel in the present case.
我们报告一例78岁男性，以持久性隆起性红斑作为非霍奇金淋巴瘤的首个临床体征。患者出现持久性隆起性红斑，其分布异常，累及躯干。持久性隆起性红斑是一种罕见的皮肤病，被认为是与肿瘤、自身免疫和感染过程相关的局限性、低度白细胞破碎性血管炎。它可能由免疫复合物介导。最近的研究报告血液系统疾病是与持久性隆起性红斑相关的最常见因素。许多血液系统疾病，如骨髓瘤、骨髓增生异常综合征和免疫球蛋白（Ig）A单克隆丙种球蛋白病，已被报道与持久性隆起性红斑有关，但与IgM单克隆丙种球蛋白病无关，与恶性淋巴瘤相关的仅1例。考虑到在本病例中持久性隆起性红斑和非霍奇金淋巴瘤的活动呈平行波动，我们想将IgM单克隆丙种球蛋白病和非霍奇金淋巴瘤添加为与持久性隆起性红斑相关的疾病之一。
