天使综合征的麻醉

Anaesthesia for Angelman syndrome.

作者信息

Ramanathan K R, Muthuswamy D, Jenkins B J

机构信息

Department of Anaesthetics, Prince Charles Hospital, Merthyr Tydfil, UK.

出版信息

Anaesthesia. 2008 Jun;63(6):659-61. doi: 10.1111/j.1365-2044.2008.05439.x.

DOI:10.1111/j.1365-2044.2008.05439.x

PMID:18477280

Abstract

We describe the administration of anaesthesia to a patient with Angelman syndrome, which is characterised by an abnormality of chromosome 15, where a subunit of the GABA receptor is coded. This has far-reaching anaesthetic implications as many drugs used in anaesthesia are thought to act via GABA receptors. Our patient had an uneventful peri-operative period and was discharged home on the second postoperative day.

摘要

我们描述了对一名患有天使综合征患者实施麻醉的情况，该综合征的特征是15号染色体异常，而γ-氨基丁酸（GABA）受体的一个亚基在该染色体上编码。这具有深远的麻醉意义，因为许多用于麻醉的药物被认为是通过GABA受体起作用的。我们的患者围手术期过程顺利，术后第二天出院回家。