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用于脂肪抑制电影心血管磁共振成像的快速相位调制水激发稳态自由进动序列

Rapid phase-modulated water excitation steady-state free precession for fat suppressed cine cardiovascular MR.

作者信息

Lin Hung-Yu, Raman Subha V, Chung Yiu-Cho, Simonetti Orlando P

机构信息

Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.

出版信息

J Cardiovasc Magn Reson. 2008 May 13;10(1):22. doi: 10.1186/1532-429X-10-22.

DOI:10.1186/1532-429X-10-22
PMID:18477396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2429911/
Abstract

BACKGROUND

The purpose of this article is to describe a steady-state free precession (SSFP) sequence for fat suppressed cine cardiovascular magnetic resonance (CMR). A rapid phase-modulated binomial water excitation (WE) pulse is utilized to minimize repetition time and acquisition time.

METHODS

Three different water-excitation pulses were combined with cine-SSFP for evaluation. The frequency response of each sequence was simulated and examined in phantom imaging studies. The ratio of fat to water signal amplitude was measured in phantoms to evaluate the fat suppression capabilities of each method. Six volunteers underwent CMR of the heart at 1.5T to compare retrospectively-gated cine-SSFP with and without water excitation. The ratio of fat to myocardium signal amplitude was measured for conventional cine-SSFP and phase-modulated WE-SSFP. The proposed WE-SSFP method was tested in one patient referred for CMR to characterize a cardiac mass.

RESULTS AND DISCUSSION

The measured frequency response in a phantom corresponded to the numerical Bloch equation simulation demonstrating the widened stop-band around the fat resonant frequency for all water-excitation pulses tested. In vivo measurements demonstrated that a rapid, phase-modulated water excitation pulse significantly reduced the signal amplitude ratio of fat to myocardium from 6.92 +/- 2.9 to 0.8 +/- 0.13 (mean +/- SD) without inducing any perceptible artifacts in SSFP cine CMR.

CONCLUSION

Fat suppression can be achieved in SSFP cine CMR while maintaining steady-state equilibrium using rapid, phase modulated, binomial water-excitation pulses.

摘要

背景

本文旨在描述一种用于脂肪抑制电影心血管磁共振成像（CMR）的稳态自由进动（SSFP）序列。采用快速相位调制二项式水激励（WE）脉冲以最小化重复时间和采集时间。

方法

将三种不同的水激励脉冲与电影SSFP相结合进行评估。在体模成像研究中模拟并检查每个序列的频率响应。在体模中测量脂肪与水信号幅度的比值，以评估每种方法的脂肪抑制能力。六名志愿者在1.5T条件下接受心脏CMR检查，以回顾性门控方式比较有无水激励的电影SSFP。测量传统电影SSFP和相位调制WE-SSFP的脂肪与心肌信号幅度比值。对一名因CMR前来检查的患者测试所提出的WE-SSFP方法，以表征心脏肿块。

结果与讨论

体模中测得的频率响应与数值布洛赫方程模拟结果相符，表明在所测试的所有水激励脉冲下，脂肪共振频率周围的阻带变宽。体内测量表明，快速相位调制水激励脉冲可将脂肪与心肌的信号幅度比值从6.92±2.9显著降低至0.8±0.13（平均值±标准差），且在SSFP电影CMR中未产生任何可察觉的伪影。

结论

在SSFP电影CMR中，使用快速相位调制二项式水激励脉冲可在保持稳态平衡的同时实现脂肪抑制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1edf/2429911/311c883ca7c6/1532-429X-10-22-9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1edf/2429911/311c883ca7c6/1532-429X-10-22-9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1edf/2429911/ad2102b69403/1532-429X-10-22-1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1edf/2429911/d1189aab7fed/1532-429X-10-22-6.jpg
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