Kajantie Eero
National Public Health Institute, Helsinki, Finland.
Hormones (Athens). 2008 Apr-Jun;7(2):101-13. doi: 10.1007/BF03401501.
During the last two decades, a considerable body of evidence has emerged showing that circumstances during the fetal period and childhood may have lifelong programming effects on different body functions with a considerable impact on disease susceptibility. From a medical point of view, these long-term effects are today referred to as the Developmental Origins of Health and Disease (DOHaD) concept. The DOHaD concept may have a fundamental impact on our ideas about when and how to intervene in order to prevent aging-related loss of function and disease. The aim of this review is to provide a synopsis of epidemiological findings relating early-life conditions with key aging-related disorders, including cardiovascular disease, type 2 diabetes, depression, cognitive impairments and osteoporosis. There are several mechanisms that have been suggested as linking early-life events with late-life disease. This review will discuss programming of the hypothalamic-pituitary-adrenal axis function as one of the best characterised examples of such mechanisms.
在过去二十年中，大量证据表明，胎儿期和儿童期的环境可能会对不同身体功能产生终身的编程效应，对疾病易感性产生重大影响。从医学角度来看，这些长期影响如今被称为健康与疾病的发育起源（DOHaD）概念。DOHaD概念可能会对我们关于何时以及如何进行干预以预防与衰老相关的功能丧失和疾病的观念产生根本性影响。本综述的目的是概述将早期生活状况与关键的与衰老相关疾病联系起来的流行病学研究结果，这些疾病包括心血管疾病、2型糖尿病、抑郁症、认知障碍和骨质疏松症。有几种机制被认为是将早期生活事件与晚年疾病联系起来的。本综述将讨论下丘脑 - 垂体 - 肾上腺轴功能的编程，将其作为此类机制中最具特征的例子之一。
