高催乳素血症对精神病患者性功能的影响。

The impact of hyperprolactinaemia on sexual function in patients with psychosis.

作者信息

Smith Shubulade M

机构信息

Institute of Psychiatry at Kings College London, Decrespigny Park, Camberwell, London, UK.

出版信息

J Psychopharmacol. 2008 Mar;22(2 Suppl):63-9. doi: 10.1177/0269881107088438.

DOI:10.1177/0269881107088438

PMID:18477622

Abstract

Sexual dysfunction is a common but significantly underestimated side effect of antipsychotic medication. It is frequently related to the hyperprolactinaemia that can be induced by dopamine-blocking properties of these agents, but may also be related to the anti-serotonergic properties or anticholinergic and antiadrenergic properties of antipsychotics. Knowledge of the receptor pharmacology of an individual antipsychotic will help to determine whether it is more or less likely to cause sexual side effects.

摘要

性功能障碍是抗精神病药物常见但被严重低估的副作用。它常与这些药物的多巴胺阻断特性所诱发的高催乳素血症有关，但也可能与抗精神病药物的抗血清素能特性、抗胆碱能和抗肾上腺素能特性有关。了解个体抗精神病药物的受体药理学将有助于确定其引起 sexual side effects 的可能性大小。（注：原文中“sexual side effects”直译为“性副作用”，在医学语境可能较难理解，这里保留英文可理解为“与性功能相关的副作用”，具体可根据上下文灵活处理，但原译文会更准确保留英文词以避免歧义）