Gaslin Michael T, Rubin Cory, Pribitkin Edmund A
Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, USA.
Ear Nose Throat J. 2008 Apr;87(4):217-20.
Long-term use of silver-containing products is associated with a permanent bluish-gray discoloration of the skin known as argyria, but they remain widely available despite several measures by the FDA to regulate them. Several recent case reports have described the occurrence of argyria as a result of using these "natural" products. We used the five most common Internet search engines to find Web sites providing information on silver-containing nasal sprays. Of 49 Web sites analyzed, only 2 (4%) mentioned argyria as a possible complication, although 30 (61%) did caution against long-term use. Eight sites (16%) made specific claims about the health benefits of the product. All 49 sites (100%) provided direct or indirect links to buy silver-containing nasal sprays. We conclude that information about silver-containing nasal sprays on the Internet is misleading and inaccurate. Therefore, otolaryngologists should be aware of the misinformation their patients may be receiving about these products.
长期使用含银产品会导致皮肤出现一种永久性的蓝灰色变色，即银质沉着症，但尽管美国食品药品监督管理局（FDA）采取了多项措施对其进行监管，这些产品仍广泛可得。最近有几例病例报告描述了使用这些“天然”产品导致银质沉着症的情况。我们使用了五个最常用的互联网搜索引擎来查找提供含银鼻喷雾剂信息的网站。在分析的49个网站中，只有2个（4%）提到银质沉着症可能是一种并发症，尽管有30个（61%）确实提醒不要长期使用。8个网站（16%）对该产品的健康益处提出了具体主张。所有49个网站（100%）都提供了购买含银鼻喷雾剂的直接或间接链接。我们得出结论，互联网上有关含银鼻喷雾剂的信息具有误导性且不准确。因此，耳鼻喉科医生应该意识到他们的患者可能正在收到有关这些产品的错误信息。
