Zhou Shi-Jie, Xu Shao-Fa, Zhang Hai-Qing, Liu Zhi-Dong
Department of Thoracic Surgery, Beijing Institute of Tuberculosis and Thoracic Tumors, Beijing 101149, China.
Zhonghua Zhong Liu Za Zhi. 2007 Dec;29(12):927-30.
To evaluate the expression of HDGF and its implication in patients who undergone radical resection for stage I non-small cell lung cancer.
Immunohistochemical technique was applied to detect the expression of HDGF in 118 lung cancer tissues and 30 normal lung tissues as control. At the same time, the expression of VEGF and Ki-67 labeling rate of the tumors was evaluated.
HDGF expression was observed in all cases, and significantly higher than that in normal lung tissues (52.23 +/- 10.35 vs. 156.73 +/- 70.95, P < 0.01). Expresson of HDGF was closely related to histological classification, and the expression in adenocarcinoma was much stronger than that in squamous cell cancers (P = 0.001), but not related to other clinicopathological factors. VEGF expression was closely related to the expression of HDGF. HDGF expression in the VEGF high expression group was much higher than that in VEGF low expression group (171.77 +/- 81.07 vs. 142.81 +/- 59.84, P = 0.028). Ki-67 expression was also closely related to the expression of HDGF, the labeling rate of Ki-67 in high HDGF expression group was much higher than that in low HDGF expression group (30.49% +/- 7.88% vs. 17.80% +/- 5.63%, P = 0.001). Univariate analysis showed that the patients with high HDGF expression had a shorter overall survival than that with low HDGF expression (40.0% vs. 77.5%, P = 0.008), and multivariate Cox regression analysis showed that HDGF was a significantly independent predictive factors for patients with stage I NSCLC (RR = 1.011, P = 0.002).
HDGF expression is upgraded in postoperative stage I non-small cell lung cancer patients. HDGF is a significantly independent predictive factor for patients with stage I NSCLC. HDGF may play an important role on carcinogenesis and development of stage I NSCLC through promoting cell proliferation and neoangiogenesis of the tumor.
评估肝癌衍生生长因子（HDGF）在Ⅰ期非小细胞肺癌根治性切除患者中的表达及其意义。
应用免疫组织化学技术检测118例肺癌组织及30例正常肺组织（作为对照）中HDGF的表达。同时，评估肿瘤组织中血管内皮生长因子（VEGF）的表达及Ki-67标记率。
所有病例均观察到HDGF表达，且显著高于正常肺组织（52.23±10.35对156.73±70.95，P<0.01）。HDGF表达与组织学分类密切相关，腺癌中的表达明显强于鳞状细胞癌（P=0.001），但与其他临床病理因素无关。VEGF表达与HDGF表达密切相关。VEGF高表达组中HDGF表达明显高于VEGF低表达组（171.77±81.07对142.81±59.84，P=0.028）。Ki-67表达也与HDGF表达密切相关，HDGF高表达组中Ki-67标记率明显高于HDGF低表达组（30.49%±7.88%对17.80%±5.63%，P=0.001）。单因素分析显示，HDGF高表达患者的总生存期短于HDGF低表达患者（40.0%对77.5%，P=0.008），多因素Cox回归分析显示，HDGF是Ⅰ期非小细胞肺癌患者的显著独立预测因素（相对危险度=1.011，P=0.002）。
Ⅰ期非小细胞肺癌术后患者HDGF表达上调。HDGF是Ⅰ期非小细胞肺癌患者的显著独立预测因素。HDGF可能通过促进肿瘤细胞增殖和新生血管生成在Ⅰ期非小细胞肺癌的发生发展中起重要作用。
