通过用2-三甲基硅氧基呋喃取代森田-贝利斯-希尔曼乙酸酯，实现手性膦催化的γ-丁内酯的对映选择性构建。
Chiral phosphine-catalyzed enantioselective construction of gamma-butenolides through substitution of Morita-Baylis-Hillman acetates with 2-trimethylsilyloxy furan.
作者信息
Jiang Ying-Qing, Shi Yong-Ling, Shi Min
机构信息
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
出版信息
J Am Chem Soc. 2008 Jun 11;130(23):7202-3. doi: 10.1021/ja802422d. Epub 2008 May 15.
Chiral multifunctional phosphine (R)-N-(2'-diphenylphosphanyl-[1,1']binaphthalenyl-2-yl)methanesulfonamide L2 or (R)-N-(2'-diphenylphosphanyl-[1,1']binaphthalenyl-2-yl)acetamide L3 is an efficient catalyst in the allylic substitutions of MBH acetates 1 with 2-trimethylsilyloxy furan 2 to provide gamma-butenolides 3 in good to excellent yields and enantiomeric excesses in the presence of water.
手性多功能膦（R）-N-（2'-二苯基膦基-[1,1']联萘基-2-基）甲磺酰胺L2或（R）-N-（2'-二苯基膦基-[1,1']联萘基-2-基）乙酰胺L3是一种高效催化剂，可使乙酸烯丙酯1与2-三甲基硅氧基呋喃2发生烯丙基取代反应，在水存在的情况下，以良好至优异的产率和对映体过量得到γ-丁内酯3。
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