Marchant Gary E
Lincoln Professor of Emerging Technologies, Law and Ethics, Center for the Study of Law, Science and Technology, Sandra Day O'Connor College of Law, Arizona State University, PO Box 877906, Tempe, AZ 85287-7906, USA.
Hum Exp Toxicol. 2008 Feb;27(2):97-107. doi: 10.1177/0960327107086567.
Policy implementation of hormesis has to date focused on regulatory applications. Toxic-tort litigation may provide an alternative policy venue for real-world applications of hormesis. Businesses and government entities, who are sued by individuals claiming to have been injured by exposure to very low levels of toxic substances may defend those cases by deploying hormesis to argue that such exposures were unlikely to be harmful. The threshold issue in using hormesis in toxic-tort defense is whether such evidence will be admissible under applicable standards for scientific evidence, which will likely turn on whether hormesis is deemed to be ;generally accepted' in the relevant scientific community. Given the relatively novel status of hormesis, its admissibility will likely be a close call, but is likely to be held admissible in favorable circumstances. If admissible, hormesis is likely to receive a fairer and more even-handed consideration than in regulatory decisions, where regulatory agencies are bound by policy-based default assumptions that limit their receptivity to new concepts such as hormesis. The perception of hormesis by juries will likely be the critical factor for determining the utility of hormesis in toxic-tort litigation, and this perception is likely to be affected by the presentation and circumstances in the individual case.
迄今为止,毒物兴奋效应的政策实施主要集中在监管应用方面。毒物侵权诉讼可能为毒物兴奋效应在现实世界中的应用提供另一种政策途径。企业和政府实体若被个人起诉,称其因接触极低水平的有毒物质而受伤,它们可能会通过运用毒物兴奋效应来为这些案件辩护,辩称此类接触不太可能有害。在毒物侵权辩护中使用毒物兴奋效应的关键问题是,根据科学证据的适用标准,此类证据是否可被采纳,这可能取决于毒物兴奋效应在相关科学界是否被视为“普遍接受”。鉴于毒物兴奋效应的相对新颖性,其可采性可能存在争议,但在有利情况下可能会被认定为可采纳。如果可被采纳,毒物兴奋效应在这种情况下可能会比在监管决策中得到更公平、更公正的考量,因为监管机构受基于政策的默认假设约束,这些假设限制了它们对毒物兴奋效应等新概念的接受程度。陪审团对毒物兴奋效应的看法可能是决定其在毒物侵权诉讼中效用的关键因素,而这种看法可能会受到个别案件的陈述情况和具体情形的影响。