Angelow Susanne, Ahlstrom Robert, Yu Alan S L
Department of Medicine, University of Southern California Keck School of Medicine, Division of Nephrology, 2025 Zonal Ave, RMR 406, Los Angeles, CA 90089, USA.
Am J Physiol Renal Physiol. 2008 Oct;295(4):F867-76. doi: 10.1152/ajprenal.90264.2008. Epub 2008 May 14.
Claudins are a family of tight junction membrane proteins that regulate paracellular permeability of epithelia, likely by forming the lining of the paracellular pore. Claudins are expressed throughout the renal tubule, and mutations in two claudin genes are now known to cause familial hypercalciuric hypomagnesemia with nephrocalcinosis. In this review, we discuss recent advances in our understanding of the physiological role of various claudins in normal kidney function, and in understanding the fundamental biology of claudins, including the molecular basis for selectivity of permeation, claudin interactions in tight junction formation, and regulation of claudins by protein kinases and other intracellular signals.
紧密连接蛋白是一类紧密连接膜蛋白家族，可能通过形成细胞旁孔的内衬来调节上皮细胞的细胞旁通透性。紧密连接蛋白在整个肾小管中表达，现在已知两个紧密连接蛋白基因的突变会导致伴有肾钙质沉着症的家族性高钙尿性低镁血症。在这篇综述中，我们讨论了在理解各种紧密连接蛋白在正常肾功能中的生理作用方面的最新进展，以及在理解紧密连接蛋白的基础生物学方面的进展，包括渗透选择性的分子基础、紧密连接形成中的紧密连接蛋白相互作用，以及蛋白激酶和其他细胞内信号对紧密连接蛋白的调节。
