Galli Stephen J, Grimbaldeston Michele, Tsai Mindy
Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5324, USA.
Nat Rev Immunol. 2008 Jun;8(6):478-86. doi: 10.1038/nri2327.
Mast cells can promote inflammation and other tissue changes in IgE-associated allergic disorders, as well as in certain innate and adaptive immune responses that are thought to be independent of IgE. However, mast cells can also have anti-inflammatory and immunosuppressive functions. Here, we review the evidence that mast cells can have negative, as well as positive, immunomodulatory roles in vivo, and we propose that mast cells can both enhance and later suppress certain features of an immune response.
肥大细胞可促进与IgE相关的过敏性疾病中的炎症及其他组织变化，以及某些被认为独立于IgE的先天性和适应性免疫反应。然而，肥大细胞也可具有抗炎和免疫抑制功能。在此，我们综述肥大细胞在体内可发挥负性及正性免疫调节作用的证据，并提出肥大细胞既能增强也能随后抑制免疫反应的某些特征。
