Section of Pharmacology, Division of Animal Biology, Biological Institute of Sao Paulo.
Avian Pathol. 1998;27(4):346-51. doi: 10.1080/03079459808419350.
Acute intoxication with Senna occidentalis seeds was studied in chicks. Seven-day-old chicks were fed ground dried seeds of this plant mixed with regular chicken ration at a concentration of 4% by weight for 15 days. Feed intake and body weight were markedly affected and a high level of lethality was observed. Necropsy examination of chicks from the experimental group revealed paleness and atrophy of thoracic muscles. Degenerative and necrotic fibres were observed in skeletal muscle by histological examination. Muscle histochemistry showed accumulation of lipids and numerous acid phosphatase-positive muscle fibres. Electron microscopy revealed atrophic muscle fibres, lipid storage, dilatation of the sarcoplasmic reticulum and abnormal mitochondria.
番泻叶种子急性中毒的研究在小鸡中进行。7 日龄小鸡喂食与常规鸡饲料以 4%重量比混合的番泻叶种子干粉，共 15 天。采食量和体重明显受到影响，死亡率高。实验组小鸡尸检显示胸部肌肉苍白和萎缩。组织学检查显示骨骼肌有退行性和坏死纤维。肌肉组织化学显示脂质堆积和大量酸性磷酸酶阳性肌纤维。电镜显示萎缩的肌纤维、脂质储存、肌浆网扩张和异常的线粒体。
