Sahashi K
Fourth Department of Medicine, Aichi Medical University.
Gan To Kagaku Ryoho. 1991 Mar;18(3):357-64.
Paraneoplastic neuromuscular syndromes reveal heterogeneous clinical features and often associate with particular tumor types. Patients presenting with one of the more distinctive syndromes, such as subacute cerebellar degeneration and Lambert-Eaton myasthenic syndrome, should undergo a careful search for detecting an occult malignancy. At present, an autoimmune pathogenesis has been clearly demonstrated only for the Lambert-Eaton syndrome. Specific autoantibodies in other syndromes may be diagnostic in identifying an underlying malignancy as a tumor marker. The precise role of antibodies in producing tissue damage and clinical manifestation is still controversial.
副肿瘤性神经肌肉综合征表现出异质性临床特征，且常与特定肿瘤类型相关。出现较为独特的综合征之一（如亚急性小脑变性和兰伯特-伊顿肌无力综合征）的患者，应仔细检查以发现隐匿性恶性肿瘤。目前，仅兰伯特-伊顿综合征的自身免疫发病机制已得到明确证实。其他综合征中的特异性自身抗体可能作为肿瘤标志物在识别潜在恶性肿瘤方面具有诊断价值。抗体在造成组织损伤和临床表现方面的确切作用仍存在争议。
