Li You, Cheng Jin-Wei, Wei Rui-Li, Hou Chun-Lin, Wang Wen-Bin, Gu Qi-Sheng, Cai Ji-Ping
Department of Ophthalmology, Second Affiliated Hospital, Second Military Medical University, Shanghai, China.
Adv Ther. 2008 May;25(5):422-9. doi: 10.1007/s12325-008-0059-1.
The purpose of this study was to evaluate the long-term effects of chitosan 0.1% and sodium hyaluronate 1.4% (Healon GV(R); Advanced Medical Optics, Santa Ana, CA, USA) on intraocular pressure (IOP) and endothelial cell loss.
This randomised study comprised 140 eyes of 140 patients with age-related cataracts undergoing phacoemulsification followed by posterior chamber intraocular lens (IOL) implantation; 70 received chitosan 0.1%, and 70 received sodium hyaluronate 1.4%. The IOP was measured with standard Goldman applanation tonometry pre-operatively and 1 day, 1 week, 1 month, 3 months, 1 year and 3 years postoperatively. Endothelial cell counts were performed pre-operatively and 1 week, 1 month, 3 months, 1 year and 3 years postoperatively using a Pro/Koester WFSCM contact endothelial microscope.
There were no significant differences found in postoperative IOP levels among the chitosan and sodium hyaluronate groups (P>0.05). No significant differences were found in postoperative mean endothelial cell counts at all time points between the chitosan and sodium hyaluronate groups (P>0.05).
Chitosan has the same effects as sodium hyaluronate on IOP and endothelium cells counts after cataract surgery and IOL implantation, and therefore may be an alternative ophthalmic viscoelastic device.
本研究旨在评估0.1%壳聚糖和1.4%透明质酸钠（Healon GV(R)；美国加利福尼亚州圣安娜市先进医学光学公司）对眼压（IOP）和内皮细胞损失的长期影响。
这项随机研究纳入了140例年龄相关性白内障患者的140只眼睛，这些患者接受了超声乳化白内障吸除术并植入后房型人工晶状体（IOL）；70只眼睛接受0.1%壳聚糖，70只眼睛接受1.4%透明质酸钠。术前以及术后1天、1周、1个月、3个月、1年和3年使用标准戈德曼压平眼压计测量眼压。术前以及术后1周、1个月、3个月、1年和3年使用Pro/Koester WFSCM接触式内皮显微镜进行内皮细胞计数。
壳聚糖组和透明质酸钠组术后眼压水平无显著差异（P>0.05）。壳聚糖组和透明质酸钠组在所有时间点的术后平均内皮细胞计数均无显著差异（P>0.05）。
壳聚糖在白内障手术和IOL植入后对眼压和内皮细胞计数的影响与透明质酸钠相同，因此可能是一种替代性眼科粘弹剂。
