Ström Oskar, Borgstrom Fredrik, Zethraeus Niklas, Johnell Olof, Lidgren Lars, Ponzer Sari, Svensson Olle, Abdon Peter, Ornstein Ewald, Ceder Leif, Thorngren Karl Goran, Sernbo Ingemar, Jonsson Bengt
Innovus, Stockholm, Sweden.
Acta Orthop. 2008 Apr;79(2):269-80. doi: 10.1080/17453670710015094.
Few economic or quality-of-life studies have investigated the long-term consequences of fragility fractures. This prospective observational data collection study assessed the cost and quality of life related to hip, vertebral, and wrist fracture 13-18 months after the fracture, based on 684 patients surviving 18 months after fracture.
Data regarding resource use and quality of life related to fractures was collected using questionnaires at 7 research centers in Sweden. Information was collected using patient records, register sources, and by asking the patient. Quality of life was estimated using the EQ-5D questionnaire. Direct and indirect costs were estimated from a societal standpoint.
The mean fracture-related cost 13-18 months after a hip, vertebral, or wrist fracture were estimated to be euro2,422, euro3,628, and euro316, respectively. Between 12 and 18 months after hip, vertebral, and wrist fracture, utility increased by 0.03, 0.05, and 0.02, respectively. Compared to prefracture levels, the mean loss in quality of life between 13 and 18 months after fracture was estimated to be 0.05, 0.11, and 0.005 for hip, vertebral, and wrist fracture.
The sample of vertebral fracture patients was fairly small and included a high proportion of fractures leading to hospitalization, but the results indicate higher long-term costs and greater loss in quality of life related to vertebral fracture than previously believed.
很少有经济或生活质量研究调查脆性骨折的长期后果。这项前瞻性观察性数据收集研究基于684例骨折后存活18个月的患者，评估了骨折后13 - 18个月与髋部、脊椎和腕部骨折相关的成本和生活质量。
在瑞典的7个研究中心使用问卷收集与骨折相关的资源使用和生活质量数据。通过患者记录、登记来源以及询问患者来收集信息。使用EQ - 5D问卷评估生活质量。从社会角度估计直接和间接成本。
髋部、脊椎或腕部骨折后13 - 18个月与骨折相关的平均成本分别估计为2422欧元、3628欧元和316欧元。在髋部、脊椎和腕部骨折后12至18个月，效用分别提高了0.03、0.05和0.02。与骨折前水平相比，骨折后13至18个月髋部、脊椎和腕部骨折的生活质量平均损失估计分别为0.05、0.11和0.005。
脊椎骨折患者样本相当小，且导致住院的骨折比例很高，但结果表明，与脊椎骨折相关的长期成本高于以往认知，生活质量损失也更大。
