Sreedhar B, Radhika P, Neelima B, Hebalkar Neha
Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500007, India.
Chem Asian J. 2008 Jul 7;3(7):1163-9. doi: 10.1002/asia.200700410.
Silica@copper (SiO2@Cu) core-shell nanoparticles were synthesized and well characterized by XRD, TEM, AFM, XPS, UV/Vis, TGA-MS, and ICP-AES techniques. The synthesized SiO2@Cu core-shell nanoparticles were employed as catalysts for the conjugate addition of amines to alpha,beta-unsaturated compounds in water to obtain beta-amino carbonyl compounds in excellent yields in shorter reaction times. Furthermore, the catalyst works well for hetero-Michael addition reactions of heteroatom nucleophiles such as thiols to alpha,beta-unsaturated compounds. As the reaction is performed in water, it allows for easy recycling of the catalyst with consistent activity.
合成了二氧化硅@铜（SiO₂@Cu）核壳纳米颗粒，并通过X射线衍射（XRD）、透射电子显微镜（TEM）、原子力显微镜（AFM）、X射线光电子能谱（XPS）、紫外/可见光谱（UV/Vis）、热重-质谱联用（TGA-MS）和电感耦合等离子体发射光谱（ICP-AES）技术对其进行了充分表征。合成的SiO₂@Cu核壳纳米颗粒被用作催化剂，用于在水中使胺与α,β-不饱和化合物进行共轭加成反应，从而在较短的反应时间内以优异的产率获得β-氨基羰基化合物。此外，该催化剂对硫醇等杂原子亲核试剂与α,β-不饱和化合物的杂迈克尔加成反应也表现良好。由于反应在水中进行，这使得催化剂能够轻松回收且活性保持一致。
