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亨廷顿舞蹈症患者在姿势改变时的心血管迷走神经调节会发生改变。

Cardiovagal modulation upon postural change is altered in Huntington's disease.

作者信息

Bär K J, Boettger M K, Andrich J, Epplen J T, Fischer F, Cordes J, Koschke M, Agelink M W

机构信息

Department of Psychiatry, Friedrich-Schiller-University, Jena, Germany.

出版信息

Eur J Neurol. 2008 Aug;15(8):869-71. doi: 10.1111/j.1468-1331.2008.02173.x. Epub 2008 May 15.

DOI:10.1111/j.1468-1331.2008.02173.x
PMID:18484985
Abstract

BACKGROUND

Cardiac autonomic nervous system (ANS) dysfunction in Huntington's disease (HD) might affect both the sympathetic and parasympathetic branch of the ANS.

RESULTS AND CONCLUSIONS

The pattern of linear heart rate variability we found in mid stage HD patients points towards a predominately reduced cardiovagal modulation compared with healthy subjects, which might influence HD patients' susceptibility for cardiovascular complications such as syncopes and cardiac arrhythmias.

摘要

背景

亨廷顿舞蹈症（HD）中的心脏自主神经系统（ANS）功能障碍可能会影响ANS的交感神经和副交感神经分支。

结果与结论

我们在HD中期患者中发现的线性心率变异性模式表明，与健康受试者相比，主要是心脏迷走神经调制降低，这可能会影响HD患者发生心血管并发症（如晕厥和心律失常）的易感性。

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