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输尿管镜治疗输尿管下段结石:15年单中心经验

Ureteroscopic management of lower ureteric calculi: a 15-year single-centre experience.

作者信息

Elashry Osama M, Elgamasy Abdelnaser K, Sabaa Magdy A, Abo-Elenien Mohamed, Omar Mohamed Adel, Eltatawy Hassan H, El-Abd Shawky A

机构信息

Urology Department, Tanta University, Tanta, Egypt.

出版信息

BJU Int. 2008 Sep;102(8):1010-7. doi: 10.1111/j.1464-410X.2008.07747.x. Epub 2008 May 15.

Abstract

OBJECTIVE

To review our 15-year experience with ureteroscopic treatment of distal ureteric calculi and to determine the impact of improved technology and techniques on the efficacy, success and complications of the procedure.

PATIENTS AND METHODS

We retrospectively reviewed the medical records of 4512 patients who underwent 5133 ureteroscopic procedures for the treatment of distal ureteric calculi at our institution from January 1991 to December 2005. The patient and stone characteristics, treatment variables and clinical outcomes were assessed. Factors such as type of ureteroscope, procedure duration, procedure success, complication rate and hospital stay were evaluated. Data obtained from a cohort of patients that underwent the procedure from 1991 to 1995 (group 1) were statistical compared with those obtained from a cohort of patients from 1996 to 2005 (group 2). Logistic regression analysis was used to identify associated factors with the major complications of ureteroscopy.

RESULTS

Overall, the stone-free rate after the procedure was 94.6%, the mean (sd; range) operative duration was 43 (15.0; 25-120) min, the intraoperative complication rate was 6.67%, the postoperative complication rate was 9.9%, and the mean (sd) hospital stay was 1.7 (1.1) days. The clinical and radiological follow-up (mean 36.8 months) for 71.3% of eligible patients detected only 12 ureteric strictures (0.23%). On comparing group 1 with group 2, the overall success of ureteroscopic stone extraction improved from 85.7% to 97.3% (P < 0.001), significant ureteric perforation decreased from 3.3% to 0.5% (P = 0.05), ureteric avulsion decreased from 1.3 to 0.1% (P < 0.05), ureteric stricture decreased from 0.7% to 0.1% (P < 0.007), the mean (sd) procedure time significantly decreased from 75 (42.9) min to 36.5 (12.5) min (P < 0.001), and the mean hospital stay significantly decreased from 2.5 (1.6) days to 0.5 (1.2) days, with a trend toward outpatient treatment. Logistic regression analysis showed a significant association of the major ureteroscopic complications with increased operative duration, type of ureteroscope used, stone impaction, stone size and surgeon experience.

CONCLUSION

The present series shows the high success rate, with minor complications, that can be achieved with ureteroscopic treatment of distal ureteric calculi. Improvements in ureteroscope design, accessories, technique and experience have led to a significant increase in the success rate and decrease in the complication rate.

摘要

目的

回顾我们15年来输尿管镜治疗输尿管下段结石的经验,并确定技术改进对该手术疗效、成功率及并发症的影响。

患者与方法

我们回顾性分析了1991年1月至2005年12月在我院接受5133次输尿管镜手术治疗输尿管下段结石的4512例患者的病历。评估患者和结石特征、治疗变量及临床结果。对输尿管镜类型、手术时长、手术成功率、并发症发生率及住院时间等因素进行评估。将1991年至1995年接受该手术的一组患者(第1组)的数据与1996年至2005年一组患者(第2组)的数据进行统计学比较。采用逻辑回归分析确定输尿管镜检查主要并发症的相关因素。

结果

总体而言,术后结石清除率为94.6%,平均(标准差;范围)手术时长为43(15.0;25 - 120)分钟,术中并发症发生率为6.67%,术后并发症发生率为9.9%,平均(标准差)住院时间为1.7(1.1)天。71.3%符合条件患者的临床及影像学随访(平均36.8个月)仅发现12例输尿管狭窄(0.23%)。比较第1组和第2组,输尿管镜取石术的总体成功率从85.7%提高至97.3%(P < 0.001),严重输尿管穿孔从3.3%降至0.5%(P = 0.05),输尿管撕脱从1.3%降至0.1%(P < 0.05),输尿管狭窄从0.7%降至0.1%(P < 0.007),平均(标准差)手术时间从75(42.9)分钟显著降至36.5(12.5)分钟(P < 0.001),平均住院时间从2.5(1.6)天显著降至0.5(1.2)天,且有门诊治疗的趋势。逻辑回归分析显示,输尿管镜主要并发症与手术时长增加、所用输尿管镜类型、结石嵌顿、结石大小及术者经验显著相关。

结论

本系列研究表明,输尿管镜治疗输尿管下段结石成功率高,并发症少。输尿管镜设计、器械、技术及经验的改进使成功率显著提高,并发症发生率降低。

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