Goyal Vinay, Chawla Jatinder M, Balhara Yatan Ps, Shukla Garima, Singh Sumit, Behari Madhuri
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
J Med Case Rep. 2008 May 17;2:160. doi: 10.1186/1752-1947-2-160.
Pentazocine, a synthetic narcotic analgesic, is commonly used for the relief of moderate to severe pain secondary to various conditions. It is usually well tolerated; however, adverse effects are not uncommon, especially when higher doses are used and when it is used in a dependent fashion. There have been reports of various complications associated with its use, including skin fibrosis, skin ulceration, abnormal skin pigmentation and symmetrical myopathy with fibrous myopathy. Fibrosis has usually been reported in the muscles at the site of injection of the drug. Being opioid in nature, it has a high abuse potential.
Here we report a case of pentazocine-induced calcific myofibrosis in a 42-year-old man involving muscles which were not injected with pentazocine.
This case highlights the care that needs to be taken when prescribing opioid analgesics, such as pentazocine, as routine painkillers. Patients who have history of substance abuse are more likely to abuse other agents, including prescription drugs. Rare consequences such as calcific myofibrosis are devastating and can cause significant lifelong disability.
喷他佐辛是一种合成麻醉性镇痛药，常用于缓解继发于各种病症的中度至重度疼痛。它通常耐受性良好；然而，不良反应并不罕见，尤其是在使用较高剂量以及以依赖方式使用时。有报告称其使用会引发各种并发症，包括皮肤纤维化、皮肤溃疡、皮肤色素沉着异常以及伴有纤维性肌病的对称性肌病。纤维化通常在药物注射部位的肌肉中被报道。因其本质上属于阿片类药物，具有很高的滥用潜力。
在此，我们报告一例42岁男性因喷他佐辛导致钙化性肌纤维化的病例，受累肌肉并非喷他佐辛的注射部位。
该病例凸显了在将阿片类镇痛药（如喷他佐辛）作为常规止痛药处方时需要谨慎。有药物滥用史的患者更有可能滥用其他药物，包括处方药。诸如钙化性肌纤维化等罕见后果具有毁灭性，可导致严重的终身残疾。
