Paltiel Ora, Yanetz Rebecca, Calderon-Margalit Ronit, Manor Orly, Sharon Nir, Harlap Susan, Friedlander Yehiel
School of Public Health, Hadassah-Hebrew University, Jerusalem, Israel.
Leuk Res. 2008 Nov;32(11):1709-14. doi: 10.1016/j.leukres.2008.04.003. Epub 2008 May 15.
Although the association between birth weight and childhood leukemia is well described, the relation between a child's birth weight and parental risk of leukemia is unknown. We linked data from the Jerusalem Perinatal Study to the Israel Cancer Registry to ascertain the incidence of leukemia in mothers and fathers in relation to their offspring's birth weight. Birth weight >or=4500 g in any of the offspring was associated with a >3-fold risk of leukemia in mothers, but not fathers. Potential mechanisms include shared exposures of high birth weight infants and their mothers, possibly to radiation or growth factors, or genetic pathways leading to both high birth weight and leukemia.
尽管出生体重与儿童白血病之间的关联已有详尽描述，但儿童出生体重与父母患白血病风险之间的关系尚不清楚。我们将耶路撒冷围产期研究的数据与以色列癌症登记处的数据相链接，以确定母亲和父亲患白血病的发病率与其子女出生体重的关系。任何一个子女出生体重≥4500克与母亲患白血病的风险增加3倍以上相关，但与父亲无关。潜在机制包括出生体重高的婴儿及其母亲可能共同接触辐射或生长因子，或存在导致出生体重高和白血病的遗传途径。
