采用具有电解电导率检测的气液色谱法分析血浆中的美达西泮、地西泮及其代谢物。
Analysis of medazepam, diazepam, and metabolites in plasma by gas-liquid chromatography with electrolytic conductivity detection.
作者信息
Pape B E, Ribick M A
出版信息
J Chromatogr. 1977 Jun 1;136(1):127-39. doi: 10.1016/s0021-9673(00)83001-0.
An improved electrolytic conductivity detector allowed the gas-liquid chromatographic analysis of medazepam, diazepam, and major metabolites in 2 ml plasma at concentrations of 20 microgram/l. The detector had a sensitivity limit of less than 1 ng (or 100 pg nitrogen) when operated in the nitrogen-selective mode and a nitrogen/carbon elemental selectivity ratio of greater than 100,000 compared to octadecane and cholesterol. Detector response when operated in various element-selective chemical modes was investigated, and its application to the analysis of the title compounds was compared to electron capture and flame ionization detection systems.
一种改进的电解电导检测器可用于对2毫升血浆中浓度为20微克/升的美达西泮、地西泮及主要代谢物进行气-液色谱分析。该检测器在氮选择性模式下运行时，灵敏度极限小于1纳克（或100皮克氮），与十八烷和胆固醇相比，氮/碳元素选择性比大于100,000。研究了该检测器在各种元素选择性化学模式下运行时的响应，并将其在分析上述化合物中的应用与电子捕获和火焰离子化检测系统进行了比较。
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