Pergam Steven A, Wang Chia C, Gardella Carolyn M, Sandison Taylor G, Phipps Warren T, Hawes Stephen E
Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Am J Obstet Gynecol. 2008 Jul;199(1):38.e1-9. doi: 10.1016/j.ajog.2008.03.052. Epub 2008 May 19.
The objective of the study was to determine the effect of hepatitis C virus (HCV) on selected maternal and infant birth outcomes.
This population-based cohort study using Washington state birth records from 2003 to 2005 compared a cohort of pregnant women identified as HCV positive from birth certificate data (n = 506) to randomly selected HCV-negative mothers (n = 2022) and drug-using HCV-negative mothers (n = 1439).
Infants of HCV-positive mothers were more likely to be low birthweight (odds ratio [OR], 2.17; 95% confidence interval [CI] 1.24, 3.80), to be small for gestational age (OR, 1.46; 95% CI, 1.00, 2.13), to need assisted ventilation (OR, 2.37; 95% CI, 1.46, 3.85), and to require neonatal intensive car unit (NICU) admission (OR, 2.91; 95% CI, 1.86, 4.55). HCV-positive mothers with excess weight gain also had a greater risk of gestational diabetes (OR, 2.51; 95% CI, 1.04, 6.03). Compared with the drug-using cohort, NICU admission and the need for assisted ventilation remained associated with HCV.
HCV-positive pregnant women appear to be at risk for adverse neonatal and maternal outcomes.
本研究的目的是确定丙型肝炎病毒（HCV）对选定的母婴出生结局的影响。
这项基于人群的队列研究使用了2003年至2005年华盛顿州的出生记录，将从出生证明数据中确定为HCV阳性的一组孕妇（n = 506）与随机选择的HCV阴性母亲（n = 2022）和吸毒的HCV阴性母亲（n = 1439）进行比较。
HCV阳性母亲的婴儿更有可能出生体重低（优势比[OR]，2.17；95%置信区间[CI] 1.24，3.80）、小于胎龄（OR，1.46；95% CI，1.00，2.13）、需要辅助通气（OR，2.37；95% CI，1.46，3.85）以及需要入住新生儿重症监护病房（NICU）（OR，2.91；95% CI，1.86，4.55）。体重过度增加的HCV阳性母亲患妊娠期糖尿病的风险也更高（OR，2.51；95% CI，1.04，6.03）。与吸毒队列相比，入住NICU和需要辅助通气仍然与HCV有关。
HCV阳性孕妇似乎有发生不良新生儿和母亲结局的风险。
