Green D M, Finklestein J Z, Breslow N E, Beckwith J B
Department of Pediatrics, Roswell Park Cancer Institute, Buffalo, New York.
Pediatr Clin North Am. 1991 Apr;38(2):475-88. doi: 10.1016/s0031-3955(16)38088-9.
Major advances have been made in the treatment of children with Wilms' tumor. Remaining areas of investigation include the role of adriamycin and the treatment of children with stage III and IV disease and the role of whole lung radiation therapy in the treatment of children with pulmonary metastases. Long-term follow up of successfully treated patients will provide valuable insight into the importance of genetic factors in the cause of Wilms' tumor.
儿童肾母细胞瘤的治疗已取得重大进展。仍有待研究的领域包括阿霉素的作用、III期和IV期疾病患儿的治疗以及全肺放射治疗在肺转移患儿治疗中的作用。对成功治疗的患者进行长期随访将为深入了解遗传因素在肾母细胞瘤病因中的重要性提供有价值的见解。
