Germann S E, Matheis F L, Rampazzo A, Burger D, Roos M, Spiess B M
Ophthalmology Section, Equine Department Vetsuisse Faculty, University of Zurich, 8057 Zurich, Switzerland.
Equine Vet J. 2008 Nov;40(7):662-5. doi: 10.2746/042516408X297426.
Only few drugs with limited efficacy are available for topical treatment of equine glaucoma.
To evaluate the effect of topical administration of 1% brinzolamide on intraocular pressure (IOP) in clinically normal horses.
Healthy mature horses (n = 20) with normal ocular findings, were studied. The IOP was measured 5 times daily (07.00, 11.00, 15.00, 19.00 and 23.00 h) over 10 days. On Days 1 and 2, baseline values were established. On Days 3-5 one eye of each horse was treated with one drop of 1% brinzolamide every 24 h immediately following the 07.00 h measurement. On Days 6-8 the same eye was treated with 1% brinzolamide every 12 h (07.00 and 19.00 h). Measurements on Days 9 and 10 documented the return of IOP to baseline values. Statistical analysis of the data was performed.
In the treated eye a significant decrease in IOP compared to baseline values was noted during both the 24 and 12 h dosing periods (P < 0.001). During the once-daily treatment protocol an IOP reduction of 3.1 +/- 13 mmHg (14%) from baseline was recorded. During the twice-daily protocol a total IOP reduction of 5.0 +/- 1.5 mmHg (21%) was achieved.
Intraocular pressure was significantly decreased by 1% brinzolamide in a once-daily and a twice-daily treatment protocol in normotensive eyes. These findings suggest that brinzolamide might also be effective in horses with an elevated IOP.
This drug may be useful for treatment of equine glaucoma.
目前用于马青光眼局部治疗的药物疗效有限且种类稀少。
评估局部应用1%布林佐胺对临床正常马匹眼压（IOP）的影响。
对20匹眼部检查正常的健康成年马进行研究。在10天内，每天5次（07:00、11:00、15:00、19:00和23:00）测量眼压。在第1天和第2天确定基线值。在第3至5天，每匹马的一只眼睛在07:00测量后立即每隔24小时滴一滴1%布林佐胺。在第6至8天，同一只眼睛每隔12小时（07:00和19:00）滴入1%布林佐胺。在第9天和第10天的测量记录眼压恢复到基线值的情况。对数据进行统计分析。
在治疗眼，与基线值相比，在24小时和12小时给药期间眼压均显著降低（P < 0.001）。在每日一次治疗方案期间，眼压从基线降低了3.1±1.3 mmHg（14%）。在每日两次治疗方案期间，眼压总共降低了5.0±1.5 mmHg（21%）。
在正常眼压的眼睛中，1%布林佐胺每日一次和每日两次治疗方案均能显著降低眼压。这些发现表明布林佐胺可能对眼压升高的马匹也有效。
这种药物可能对马青光眼的治疗有用。
