Chabowska Anna M, Sulkowska Mariola, Chabowski Adrian, Wincewicz Andrzej, Koda Mariusz, Sulkowski Stanislaw
Department of Clinical and General Pathomorphology, Medical University of Bialystok, Bialystok, Poland.
Int J Surg Pathol. 2008 Jul;16(3):269-76. doi: 10.1177/1066896908315796. Epub 2008 May 15.
Erythropoietin via erythropoietin receptor effectively prevents anemia, giving reasons for a clinical use of erythropoietin in patients with colorectal cancers. However, erythropoietin seems to promote survival of the neoplastic cells in hypoxic environment. The aim of this study was to evaluate immunohistochemically the expression of erythropoietin and erythropoietin receptor in 136 primary colorectal cancers with a correlation to different anatomo-clinical features. Erythropoietin correlated with erythropoietin receptor in colorectal cancers (r = 0.547, P < .00001). Erythropoietin and erythropoietin receptor expressions were statistically higher in adenocarcinomas versus mucinous carcinomas (P = .05 and P = .03, respectively) and in moderately (G2) versus poorly differentiated (G3) tumors (P = .001 and P = .02, respectively). This in vivo study is the first study that provides evidences for the presence of erythropoietin and erythropoietin receptor in human colorectal cancer. The expressions of these proteins strictly depended on grading because the better histological differentiation probably comes from trophic influence of erythropoietin and erythropoietin receptor.
促红细胞生成素通过促红细胞生成素受体可有效预防贫血，这为促红细胞生成素在结直肠癌患者中的临床应用提供了依据。然而，促红细胞生成素似乎能促进肿瘤细胞在低氧环境中的存活。本研究旨在通过免疫组织化学方法评估136例原发性结直肠癌中促红细胞生成素和促红细胞生成素受体的表达，并分析其与不同解剖临床特征的相关性。在结直肠癌中，促红细胞生成素与促红细胞生成素受体相关（r = 0.547，P <.00001）。腺癌中促红细胞生成素和促红细胞生成素受体的表达在统计学上高于黏液腺癌（分别为P =.05和P =.03），在中度分化（G2）肿瘤中高于低分化（G3）肿瘤（分别为P =.001和P =.02）。这项体内研究是第一项提供证据证明人结直肠癌中存在促红细胞生成素和促红细胞生成素受体的研究。这些蛋白质的表达严格依赖于分级，因为更好的组织学分化可能源于促红细胞生成素和促红细胞生成素受体的营养作用。
