Ranck R S, Linder K E, Haber M D, Meuten D J
Department of Population Health and Pathobiology, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA.
Vet Pathol. 2008 May;45(3):361-4. doi: 10.1354/vp.45-3-361.
A primary intimal aortic angiosarcoma was diagnosed in a 4-year-old, spayed female German Shepherd that presented for complications of thromboembolic disease because of infarcts in multiple organs. On gross examination, aneurysmal dilatation of the aorta was associated with a friable, necrotic mass attached to the endothelial surface, which partially occluded the aortic lumen. On histologic examination, plump neoplastic spindle cells formed a plaque-like mass arising from the intima that merged with a large accumulation of fibrin and necrotic debris, and projected into the lumen. Neoplastic cells invaded periaortic vessels and were seen in some infarct-associated thromboemboli. Tumor cells expressed vimentin and CD31, with infrequent, patchy staining with factor VIII-related antigen; tumor cells were negative for cytokeratin and smooth-muscle actin. Aortic angiosarcoma is a rare malignancy in humans. This is the first description of a primary intimal aortic angiosarcoma in a dog, with immunohistochemical evidence of endothelial origin.
一只4岁已绝育的雌性德国牧羊犬被诊断为原发性主动脉内膜血管肉瘤，该犬因多器官梗死导致血栓栓塞性疾病并发症前来就诊。大体检查发现，主动脉瘤样扩张与附着在内皮表面的易碎坏死肿块相关，该肿块部分阻塞了主动脉腔。组织学检查显示，丰满的肿瘤性梭形细胞形成了一个斑块样肿块，起源于内膜，与大量纤维蛋白和坏死碎片融合，并突入管腔。肿瘤细胞侵犯了主动脉周围血管，并在一些与梗死相关的血栓栓子中可见。肿瘤细胞表达波形蛋白和CD31，因子VIII相关抗原染色少见且呈斑片状；肿瘤细胞细胞角蛋白和平滑肌肌动蛋白呈阴性。主动脉血管肉瘤在人类中是一种罕见的恶性肿瘤。这是首次对犬原发性主动脉内膜血管肉瘤的描述，并具有内皮起源的免疫组化证据。
