Yao Ke-Wen, Wang Jie-Dong
Graduate School of Peking Union Medical College, Beijing 100730, China.
Zhonghua Nan Ke Xue. 2008 Mar;14(3):268-71.
As a new type of pesticides and because of their high performance and low toxicity, pyrethroid insecticides are widely used in place of organochlorine insecticides both in agriculture and in the home. In the recent years, more and more evidence indicates that pyrethroid insecticides can reduce sperm count and motility, cause deformity of the sperm head, increase the count of abnormal sperm, damage sperm DNA and induce its aneuploidy rate, as well as affect sex hormone levels and produce reproductive toxicity. The present article reviews the advances in the studies of male reproductive toxicity of pyrethroid pesticides by experiment in animals and human population, discusses the mechanism of male reproductive toxicity of pesticides and raises some problems concerning the evaluation of human reproductive hazards.
作为一种新型农药,拟除虫菊酯类杀虫剂因其高效低毒,在农业和家庭中被广泛用于替代有机氯杀虫剂。近年来,越来越多的证据表明,拟除虫菊酯类杀虫剂可降低精子数量和活力,导致精子头部畸形,增加异常精子数量,损伤精子DNA并诱导其非整倍体率,还会影响性激素水平并产生生殖毒性。本文综述了拟除虫菊酯类农药对雄性生殖毒性的动物实验和人群研究进展,探讨了农药雄性生殖毒性的作用机制,并提出了一些关于人类生殖危害评估的问题。