Kukleva L M, Eroshenko G A, Kuklev V E, Shavina N Iu, Krasnov Ia M, Guseva N P, Kutyrev V V
Mol Gen Mikrobiol Virusol. 2008(2):23-7.
A study of the structural and regulatory genes, determining rhamnose fermentation, that are located in the rha locus of the chromosome of Yersinia pestis main and non-main subspecies and of Yersinia pseudotuberculosis of serogroups I-III was performed. The nucleotide sequence of Y. pestis main subspecies differs substantially from those of non-main subspecies and Y. pseudotuberculosis by the presence of a nucleotide substitution in 671 bp location of rhaS gene resulting presumably in the Y. pestis non-main subsp inability to utilize rhamnose. This results in incapability of Y. pestis non-main subspecies to utilize rhamnose. Other nucleotide substitutions found in Y. pestis non-main subspecies strains influence only upon expression efficiency of this diagnostic criterion.
对位于鼠疫耶尔森氏菌主要和非主要亚种以及血清群I-III假结核耶尔森氏菌染色体rha位点上决定鼠李糖发酵的结构和调控基因进行了研究。鼠疫耶尔森氏菌主要亚种的核苷酸序列与非主要亚种和假结核耶尔森氏菌的核苷酸序列有很大差异，原因是rhaS基因671bp位置存在核苷酸取代，这可能导致鼠疫耶尔森氏菌非主要亚种无法利用鼠李糖。这导致鼠疫耶尔森氏菌非主要亚种无法利用鼠李糖。在鼠疫耶尔森氏菌非主要亚种菌株中发现的其他核苷酸取代仅影响该诊断标准的表达效率。
