Zubkova O V, Logunov D Iu, Karpov A P, Shmarov M M, Belousova R V, Naroditskiĭ B S
Mol Gen Mikrobiol Virusol. 2008(2):32-6.
Recombinant avian adenovirus CELO bearing sequence RGD in the structure of a HI-loop of long fiber was designed. Experiments in vitro revealed that introduction of RGD-motif into fiber of CELO increased the ability of the virus to be attached to a surface of CAR-negative cells, and raised efficiency of the process of internalization of the virus both in CAR-positive, and in CAR-negative cells.
设计了在长纤维HI环结构中带有RGD序列的重组禽腺病毒CELO。体外实验表明，将RGD基序引入CELO纤维中可增强病毒附着于CAR阴性细胞表面的能力，并提高病毒在CAR阳性细胞和CAR阴性细胞中的内化效率。
