Pokrovskiĭ M V, Pokrovskaia T G, Kochkarov V I, Artiushkova E B
Eksp Klin Farmakol. 2008 Mar-Apr;71(2):29-31.
In laboratory animals with endothelial dysfunction (nitric oxide deficiency) modeled by the introduction of NO-synthase inhibitor L-NAME, the activation of endothelioprotective effects of enalapril, lozartan, amlodipine, indapamide and nebivolol is revealed for their introduction in combination with L-arginine. This result was confirmed by the behavior of a generalizing parameter, the coefficient of endothelial dysfunction (CED) calculated using the results of tests on endothelium-dependent and -independent vasodilation.
在通过引入一氧化氮合酶抑制剂L-NAME建立内皮功能障碍（一氧化氮缺乏）模型的实验动物中，研究发现，将依那普利、氯沙坦、氨氯地平、吲达帕胺和奈必洛尔与L-精氨酸联合使用时，可激活它们的内皮保护作用。这一结果通过一个综合参数——内皮功能障碍系数（CED）得到证实，该系数是根据内皮依赖性和非依赖性血管舒张试验结果计算得出的。
