Institute of Dermatology and Plastic Surgery, University of Modena and Reggio Emilia, Modena, Italy.
Int J Cosmet Sci. 2006 Aug;28(4):255-61. doi: 10.1111/j.1467-2494.2006.00321.x.
Melanocytes and cells of the nervous system are of common ectodermal origin and neurotrophins (NT) have been shown to be released by human keratinocytes. We investigated the expression and function of NT [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT-3, NT-4/-5] and their receptors in human melanocytes. Human melanocytes produce all NT in different amounts, whereas they only release NT-4. NT-4 release is downregulated, whereas NT-3 is upregulated by ultraviolet (UVB) irradiation. Melanocytes treated with phorbol 12-myristate 13-acetate (PMA) express TrkA and TrkB, but not TrkC. NT fail to stimulate melanocyte proliferation, whereas they stimulate the synthesis of tyrosinase and tyrosinase-related protein-1 (TRP-1). Finally, NT-3, NT-4 and NGF increase melanin production. Taken together, these results demonstrate an intriguing interaction between melanocytes and the nervous system. We speculate that NT could be considered the target of therapy for disorders of skin pigmentation.
黑素细胞和神经系统细胞具有共同的外胚层起源，神经生长因子（NT）已被证明可由人角质形成细胞释放。我们研究了 NT[神经生长因子（NGF）、脑源性神经营养因子（BDNF）、NT-3、NT-4/-5]及其受体在人黑素细胞中的表达和功能。人黑素细胞以不同的量产生所有 NT，但仅释放 NT-4。紫外线（UVB）照射可下调 NT-4 的释放，而上调 NT-3 的表达。用佛波醇 12-肉豆蔻酸 13-乙酸酯（PMA）处理的黑素细胞表达 TrkA 和 TrkB，但不表达 TrkC。NT 不能刺激黑素细胞增殖，但能刺激酪氨酸酶和酪氨酸酶相关蛋白-1（TRP-1）的合成。最后，NT-3、NT-4 和 NGF 增加黑色素的产生。综上所述，这些结果表明黑素细胞和神经系统之间存在有趣的相互作用。我们推测，NT 可被视为皮肤色素沉着紊乱治疗的靶点。
