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[在亚致死和致死剂量γ辐射条件下倍他米松的抗辐射特性]

[The antiradiation properties of betamide under conditions of sublethal and lethal gamma irradiation].

作者信息

Tenchova V B, Pantev T P

出版信息

Radiobiologiia. 1991 Jan-Feb;31(1):151-3.

PMID:1848942
Abstract

Bone marrow cellularity in the femur, mass and cellularity of the spleen and small intestine, and nucleic acid concentration in the leukocyte mass of blood were investigated after the intraperitoneal administration of betamide (500 mg/kg) 15 min before gamma irradiation of mice with doses of 4, 7 and 9 Gy. The number of myelokaryocytes and splenocytes in the protected animals was shown to exceed considerably that in the controls on days 3 and 9 after irradiation with the three doses. With betamide injected on day 9 following irradiation the number of nucleated cells of the small intestine was larger and the nucleic acid concentration in leukocytes higher than the same indices in the irradiated control.

摘要

在以4、7和9 Gy剂量对小鼠进行γ射线照射前15分钟腹腔注射倍他米松(500 mg/kg)后,对股骨中的骨髓细胞成分、脾脏和小肠的质量及细胞成分,以及血液白细胞团中的核酸浓度进行了研究。结果显示,在接受这三种剂量照射后的第3天和第9天,受保护动物的骨髓有核细胞和脾细胞数量大大超过对照组。在照射后第9天注射倍他米松时,小肠有核细胞数量更多,白细胞中的核酸浓度高于照射对照组的相应指标。

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