Serrão Vasco, Caldas Lopes Luísa, Campos Lopes J M, Lobo Lurdes, Ferreira Ana
Serviço de Dermatologia, Hospital dos Capuchos, Lisboa.
Acta Med Port. 2008 Jan-Feb;21(1):99-102. Epub 2008 Apr 18.
Acute generalized exanthematous pustulosis (AGEP) usually presents with the acute appearance of oedematous and erythematous lesions, on which multiple sterile pustules appear, associated with fever. Almost 90% of cases are associated with drugs, with antibiotics (penicillins and macrolides) being the most frequent causative agents. We describe a 36-year-old female patient, which started diltiazem 120mg/day for hypertension. After 6 days of therapy, multiple erythematous and oedematous lesions appeared, with associated multiple small non-follicular pustules. Oral corticosteroids were started, with progressive and complete improvement. Patch-tests were performed, which revealed positivity for diltiazem. Although a rare entity, AGEP must be considered in cases of acute eruptions with disseminated pustules and fever. The use of patch tests in this disease may be useful as positive reactions are frequent.
急性泛发性发疹性脓疱病（AGEP）通常表现为急性出现的水肿性和红斑性皮损，其上出现多个无菌性脓疱，并伴有发热。几乎90%的病例与药物有关，抗生素（青霉素和大环内酯类）是最常见的致病因素。我们描述了一名36岁的女性患者，她开始每天服用120mg地尔硫䓬治疗高血压。治疗6天后，出现多个红斑性和水肿性皮损，并伴有多个小的非毛囊性脓疱。开始口服皮质类固醇治疗，病情逐渐完全改善。进行了斑贴试验，结果显示对地尔硫䓬呈阳性反应。尽管AGEP是一种罕见的疾病，但在出现播散性脓疱和发热的急性皮疹病例中必须考虑到该病。在这种疾病中使用斑贴试验可能有用，因为阳性反应很常见。
