Nakagawa M, Kobayashi K, Sawada S, Toyoda T, Shirai K, Katoh K, Yamamoto K, Tsuji H, Sasaki S, Takeda K
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Am J Hypertens. 1991 Jan;4(1 Pt 2):54S-55S. doi: 10.1093/ajh/4.1.54s.
This study was conducted to evaluate the effects of an SH-radical in an angiotensin converting enzyme (ACE) inhibitor on PGI2 generation, intracellular cGMP, and Ca2+ kinetics in vascular endothelial cells. In the cultured human umbilical vein endothelial cells, the non-SH containing ACE inhibitors, delapril and enalapril, did not result in significant changes in cGMP concentrations. By comparison, captopril significantly (P less than .01) increased cGMP concentrations. Only captopril showed a significant (P less than .01) effect on 45Ca kinetics in cultured human vascular endothelial cells. Captopril also decreased PGI2 generation in vascular endothelial cells. These effects were not seen with delapril or enalapril. The significance of the SH moiety in ACE inhibitors remains controversial. However, these results suggest that there could be differences in the vascular actions of ACE inhibitors related to the presence or absence of SH radical.
本研究旨在评估血管紧张素转换酶（ACE）抑制剂中SH基团对血管内皮细胞中前列环素（PGI2）生成、细胞内环磷酸鸟苷（cGMP）及钙离子（Ca2+）动力学的影响。在培养的人脐静脉内皮细胞中，不含SH基团的ACE抑制剂地拉普利和依那普利并未导致cGMP浓度发生显著变化。相比之下，卡托普利显著（P<0.01）增加了cGMP浓度。仅卡托普利对培养的人血管内皮细胞中的45Ca动力学有显著（P<0.01）影响。卡托普利还降低了血管内皮细胞中PGI2的生成。地拉普利或依那普利未出现这些作用。ACE抑制剂中SH基团的意义仍存在争议。然而，这些结果表明，与SH基团的有无相关，ACE抑制剂的血管作用可能存在差异。
