Foulds G, Hilligoss D M, Henry E B, Gerber N
Central Research Division, Pfizer, Inc., Groton, Connecticut.
J Clin Pharmacol. 1991 Feb;31(2):164-7. doi: 10.1002/j.1552-4604.1991.tb03701.x.
The effects of an antacid and of cimetidine on the serum concentrations of azithromycin were examined in volunteers. Ten subjects were given 500 mg azithromycin alone and immediately after being given 30 mL Maalox (Rorer, Fort Washington, PA) in a crossover design. There were no statistically significant differences in Tmax or AUC0-48 after administration of azithromycin alone or with antacid, but mean values of Cmax were reduced by 24% (P = .015). Thus, although Cmax was decreased, the extent of absorption of azithromycin was not affected by coadministration with an antacid. Two groups of six volunteers were given 500 mg azithromycin on day 1. On day 8, one group was given 800 mg cimetidine 2 hours before a dose of azithromycin; the remaining group received placebo before azithromycin. There were no differences in the pharmacokinetic parameters produced by administration with cimetidine or placebo, relative to those on day 1. Thus, cimetidine administered 2 hours before a dose of azithromycin had no apparent effect on the serum concentrations of azithromycin.
在志愿者中研究了抗酸剂和西咪替丁对阿奇霉素血清浓度的影响。采用交叉设计，10名受试者单独服用500mg阿奇霉素，并在服用30mL氢氧化铝镁（Rorer公司，宾夕法尼亚州华盛顿堡）后立即服用。单独服用阿奇霉素或与抗酸剂合用时，Tmax或AUC0 - 48无统计学显著差异，但Cmax的平均值降低了24%（P = 0.015）。因此，虽然Cmax降低，但阿奇霉素的吸收程度不受与抗酸剂合用的影响。两组各6名志愿者在第1天服用500mg阿奇霉素。在第8天，一组在服用阿奇霉素前2小时给予800mg西咪替丁；其余一组在服用阿奇霉素前接受安慰剂。与第1天相比，服用西咪替丁或安慰剂后的药代动力学参数无差异。因此，在服用阿奇霉素前2小时给予西咪替丁对阿奇霉素的血清浓度无明显影响。
