前列腺素对肝脏及可移植性肝癌细胞膜中腺苷酸环化酶活性的影响。
Effect of prostaglandins on adenylate cyclase activities in membranes from liver and transplantable hepatomas.
作者信息
Pradhan T K, Criss W E
出版信息
Cancer Biochem Biophys. 1976 Aug;1(5):239-43.
The effects of prostaglandins on adenylate cyclase activity have been examined in membranes purified from normal rat liver and from a series of Morris hepatomas. Prostaglandin E1 gave the greatest stimulation (up to two-fold) in all membranes. However, prostaglandins A1, A2, and F2alpha, although stimulatory in liver and four tumor membranes, were inhibitory of adenylate cyclase activity in membranes from two of the fast-growing tumors. Arrhenius plots yielded broken line curves (at 20 degrees C) for the basal activity of all enzymes. Addition of various prostaglandins caused shifts in the broken line curves and/or produced nonbroken (straight) line curves for the liver and many of the hepatoma adenylate cyclases.
已对从正常大鼠肝脏和一系列莫里斯肝癌中纯化的细胞膜中前列腺素对腺苷酸环化酶活性的影响进行了研究。前列腺素E1在所有细胞膜中产生的刺激作用最大（高达两倍）。然而，前列腺素A1、A2和F2α虽然在肝脏和四种肿瘤细胞膜中具有刺激作用，但在两种快速生长的肿瘤细胞膜中却抑制腺苷酸环化酶活性。阿伦尼乌斯曲线显示所有酶的基础活性呈现折线曲线（在20摄氏度时）。添加各种前列腺素会导致折线曲线发生偏移，和/或使肝脏及许多肝癌腺苷酸环化酶产生非折线（直线）曲线。
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