Lifford Karen L, Townsend Mary K, Curhan Gary C, Resnick Neil M, Grodstein Francine
Department of Medicine, Channing Laboratory, School of Public Health, Harvard University, Boston, Massachusetts, USA.
J Am Geriatr Soc. 2008 Jul;56(7):1191-8. doi: 10.1111/j.1532-5415.2008.01747.x. Epub 2008 May 19.
To examine the epidemiology of urinary incontinence (UI) in older women.
Prospective study.
Nurses' Health Study.
Incidence of UI was determined in 23,792 women aged 54 to 79 without UI at baseline. Progression or remission of UI was determined in 28,813 women with UI at least monthly at baseline.
UI was ascertained according to questionnaires in 2000 and 2002. Rates of incident UI and progression or remission of prevalent UI were calculated. Logistic regression was used to estimate relative risks of UI associated with risk factors.
In women with no urine leakage at baseline, 9.2% reported leakage at least monthly after 2 years. For women with leakage at least weekly, the incidence was 3.6%; of these cases, stress UI had the highest incidence, followed by mixed and urge UI. Relationships between UI and age differed for stress UI, which decreased with age (relative risk (RR)=0.63, 95% confidence interval (CI)=0.43-0.92 for aged 70-79 vs 54-59), and urge and mixed UI, which increased with age (RR=2.28, 95% CI=1.09-4.75 and RR=2.11, 95% CI=1.24-3.61, respectively). For prevalent UI in 2000, 32.1% of subjects with leakage once a month progressed to leakage at least once a week over follow-up. Only 8.9% with frequent leakage in 2000 reported improvement to monthly leakage or less, with 2.0% having complete remission.
The incidence of UI is high in older women, and progression from occasional to frequent leaking is common. Urge UI, for which there are limited effective treatments, increases with age, thus research on UI prevention in older women is particularly important.
研究老年女性尿失禁(UI)的流行病学情况。
前瞻性研究。
护士健康研究。
在23792名基线时无尿失禁的54至79岁女性中确定尿失禁的发病率。在28813名基线时至少每月有尿失禁的女性中确定尿失禁的进展或缓解情况。
通过2000年和2002年的问卷调查确定尿失禁情况。计算尿失禁的发病率以及现患尿失禁的进展或缓解率。采用逻辑回归估计与危险因素相关的尿失禁相对风险。
在基线时无漏尿的女性中,9.2%报告在2年后至少每月漏尿一次。对于至少每周漏尿一次的女性,发病率为3.6%;在这些病例中,压力性尿失禁的发病率最高,其次是混合性和急迫性尿失禁。压力性尿失禁与年龄的关系有所不同,随着年龄增长其发病率下降(70 - 79岁与54 - 59岁相比,相对风险(RR)=0.63,95%置信区间(CI)=0.43 - 0.92),而急迫性和混合性尿失禁则随年龄增长而增加(RR分别为2.28,95% CI = 1.09 - 4.75和RR = 2.11,95% CI = 1.24 - 3.61)。对于2000年的现患尿失禁,在随访期间,每月漏尿一次的受试者中有32.1%进展为至少每周漏尿一次。2000年频繁漏尿的受试者中只有8.9%报告改善为每月漏尿一次或更少,2.0%完全缓解。
老年女性尿失禁的发病率较高,且从偶尔漏尿发展为频繁漏尿很常见。有效治疗方法有限的急迫性尿失禁随年龄增长而增加,因此对老年女性尿失禁预防的研究尤为重要。