Lombardi G, Merola B, Colao A, Miletto P, De Chiara G, Spaziante R, La Tessa G, Di Renzo G, Annunziato L
Institute of Endocrine Sciences, 2nd School of Medicine, University of Naples, Italy.
Acta Endocrinol (Copenh). 1991 Mar;124(3):258-66. doi: 10.1530/acta.0.1240258.
The present study aimed at evaluating the anterior pituitary hormone levels in the inferior petrosal sinuses and in the peripheral blood of 55 patients affected by various pituitary disorders and undergoing perihypophysial phlebography on neurosurgical indication or for diagnostic purposes. The results indicated that in 6 patients with Cushing's disease and in 4 with hyperprolactinemia the secreting adenoma could be localized by inferior petrosal sinus sampling. Furthermore, the concentrations of all the pituitary hormones were found to be higher in the right and/or in the left inferior petrosal sinus than in peripheral blood, showing a clear gradient between central and peripheral samples. Moreover, the evaluation of hormone central/peripheral concentration ratios revealed noteworthy differences, namely, that central/peripheral concentration ratios of GH, ACTH, and PRL were significantly higher than those of TSH, FSH, and LH (p less than 0.01). On the contrary, no significant differences were found when the concentration ratios of GH, ACTH and PRL or TSH, FSH and LH were compared among themselves. This finding may be attributed to at least two factors: the increased pulsatility and the relatively short biological halftime of polypeptic hormones (GH, ACTH, and PRL) compared with glycoprotein hormones (TSH, FSH, and LH).
本研究旨在评估55例患有各种垂体疾病且因神经外科指征或诊断目的而接受垂体周围静脉造影的患者岩下窦及外周血中的垂体前叶激素水平。结果表明，在6例库欣病患者和4例高泌乳素血症患者中，分泌性腺瘤可通过岩下窦采样定位。此外，发现所有垂体激素在右侧和/或左侧岩下窦中的浓度高于外周血，显示出中央样本和外周样本之间存在明显梯度。此外，激素中央/外周浓度比的评估显示出显著差异，即生长激素（GH）、促肾上腺皮质激素（ACTH）和泌乳素（PRL）的中央/外周浓度比显著高于促甲状腺激素（TSH）、促卵泡激素（FSH）和促黄体生成素（LH）（p<0.01）。相反，当比较GH、ACTH和PRL或TSH、FSH和LH的浓度比时，未发现显著差异。这一发现可能至少归因于两个因素：与糖蛋白激素（TSH、FSH和LH）相比，多肽激素（GH、ACTH和PRL）的脉动性增加以及生物半衰期相对较短。
