Verbenko D A, Limborskaia S A
Mol Gen Mikrobiol Virusol. 2008(2):3-11.
Minisatellite loci are a part of the human genome, playing an important role in various genomic and population studies. The review describes characteristics of this group of hypervariable tandem repeats and models that explain the reasons for their high diversity. The use of this kind of markers in population genetics studies is demonstrated by an example of the D1S80 minisatellite locus. Particular emphasis was placed on the D1S80 diversity in different populations of Eastern Europe. The capabilities of D1S80 for population analyses that allow the resolution of both main human groups and small differences to be resolved in population structures.
微卫星基因座是人类基因组的一部分,在各种基因组和群体研究中发挥着重要作用。这篇综述描述了这类高变串联重复序列的特征以及解释其高多样性原因的模型。以D1S80微卫星基因座为例展示了这类标记在群体遗传学研究中的应用。特别强调了东欧不同群体中D1S80的多样性。D1S80在群体分析方面的能力使得既能分辨主要人类群体,又能分辨群体结构中的细微差异。