Hurtado J, Esbrit P, Rapado A
Laboratorio de la Unidad Metabólica, Fundación Jiménez Diaz-C.S.I.C., Madrid, Spain.
Eur J Cancer. 1991;27(1):76-9. doi: 10.1016/0277-5379(91)90066-m.
The rat Walker carcinosarcoma 256 is an animal model for humoral hypercalcaemia of malignancy (HHM). In this model, the relative contribution of bone and kidney in the hypercalcaemia of tumour-bearing rats was investigated. Daily administration of pamidronate, a bone resorption inhibitor, for 2 days prevented the increased fasting Ca2+ excretion observed in the hypercalcaemic rats, although serum Ca2+ remained high. However, the high serum Ca2+ normalised after the acute injection of ethiofos, an inhibitor of renal Ca2+ reabsorption, which was associated with a marked increase of Ca2+ excretion. Changes in Ca2+ were accompanied by similar changes in Mg2+. The results indicate that altered renal Ca2+ handling has a key role in the hypercalcaemia associated with this HHM model.
大鼠沃克癌肉瘤256是恶性肿瘤体液性高钙血症（HHM）的动物模型。在此模型中，研究了骨骼和肾脏在荷瘤大鼠高钙血症中所起的相对作用。连续2天每日给予骨吸收抑制剂帕米膦酸盐，可防止高钙血症大鼠出现空腹Ca2+排泄增加，尽管血清Ca2+仍维持在较高水平。然而，急性注射肾Ca2+重吸收抑制剂依替膦酸后，高血清Ca2+恢复正常，这与Ca2+排泄显著增加有关。Ca2+的变化伴随着Mg2+的类似变化。结果表明，肾Ca2+处理的改变在与该HHM模型相关的高钙血症中起关键作用。
