Rückinger Simon, von Kries Rüdiger, Reinert Ralf René, van der Linden Mark, Siedler Annette
University of Munich, Institute of Social Pediatrics and Adolescent Medicine, Division of Epidemiology, Germany.
Vaccine. 2008 Jul 29;26(32):3984-6. doi: 10.1016/j.vaccine.2008.04.031. Epub 2008 May 5.
Based on active prospective surveillance, we report the incidence and serotype distribution for invasive pneumococcal disease in German children between 1997 and 2003. While incidence of meningitis cases was stable over time, there was an increase in non-meningitis cases. In absence of a general pneumococcal conjugate vaccination program, there were considerable and significant changes in serotype distribution over time. These should be considered when discussing the effect of vaccination programs and related changes in serotype distribution.
基于主动前瞻性监测，我们报告了1997年至2003年间德国儿童侵袭性肺炎球菌疾病的发病率和血清型分布情况。虽然脑膜炎病例的发病率随时间保持稳定，但非脑膜炎病例有所增加。在没有全面肺炎球菌结合疫苗接种计划的情况下，血清型分布随时间发生了相当大且显著的变化。在讨论疫苗接种计划的效果以及血清型分布的相关变化时，应考虑到这些情况。
