皮肤附属器发育中的肿瘤坏死因子超家族。

TNF superfamily in skin appendage development.

作者信息

Mikkola Marja L

机构信息

Developmental Biology Program, Institute of Biotechnology, University of Helsinki, P.O. Box 56, 00014 Helsinki, Finland.

出版信息

Cytokine Growth Factor Rev. 2008 Jun-Aug;19(3-4):219-30. doi: 10.1016/j.cytogfr.2008.04.008. Epub 2008 May 20.

DOI:10.1016/j.cytogfr.2008.04.008

PMID:18495521

Abstract

The development of skin appendages such as hairs, teeth, and mammary glands is regulated by signaling molecules of the Wnt, FGF, TGFbeta, and Hedgehog pathways. Last decade has also revealed a pivotal role for the TNF family ligand ectodysplasin (Eda) in multiple steps of epithelial appendage morphogenesis, from initiation to differentiation. Surprisingly, other members of the TNF superfamily such as Rank ligand, lymphotoxins, and TNF have recently been linked with specific aspects of skin appendage biology including branching of the mammary gland, hair shaft formation, and hair follicle cycling. This review focuses on the novel discoveries of Eda and other TNF related cytokines in skin appendage development made since the previous review on this topic in Cytokine and Growth Factor reviews in 2003.

摘要

毛发、牙齿和乳腺等皮肤附属器的发育受Wnt、FGF、TGFβ和Hedgehog信号通路的信号分子调控。过去十年还揭示了肿瘤坏死因子（TNF）家族配体外胚层发育不良蛋白（Eda）在上皮附属器形态发生的多个步骤中，从起始到分化，都起着关键作用。令人惊讶的是，TNF超家族的其他成员，如核因子κB受体活化因子配体（Rank ligand）、淋巴毒素和TNF，最近已被发现与皮肤附属器生物学的特定方面有关，包括乳腺分支、毛干形成和毛囊周期性变化。本综述重点关注自2003年在《细胞因子与生长因子评论》上一次关于该主题的综述以来，Eda和其他TNF相关细胞因子在皮肤附属器发育方面的新发现。