Nishijo J, Nagai M
Kobe Women's College of Pharmacy, Japan.
J Pharm Sci. 1991 Jan;80(1):58-62. doi: 10.1002/jps.2600800115.
The interaction of 8-anilinonaphthalene-1-sulfonate with beta-cyclodextrin was investigated in 0.1 M phosphate buffer at pH 7.4 by fluorescence spectrophotometry. Utilizing the fact that the fluorescence intensity of 8-anilinonaphthalene-1-sulfonate increases in the presence of beta-cyclodextrin, the thermodynamic parameters for the inclusion complex formation were determined as follows: delta G degrees = -2.52 kcal/mol at 25 degrees C, delta H degree = -1.92 kcal/mol, and delta S degree = 2.1 eu. The driving forces for the inclusion complex formation were considered to be van der Waals-London dispersion force and hydrophobic interaction. Also, from the measurements of 1H NMR spectra and from studying the Corey-Pauling-Koltun (CPK) model, the structure of the inclusion complex was discussed.
在pH 7.4的0.1 M磷酸盐缓冲液中，采用荧光分光光度法研究了8-苯胺基萘-1-磺酸盐与β-环糊精的相互作用。利用8-苯胺基萘-1-磺酸盐在β-环糊精存在下荧光强度增加这一事实，测定了包合物形成的热力学参数如下：25℃时，ΔG° = -2.52 kcal/mol，ΔH° = -1.92 kcal/mol，ΔS° = 2.1 eu。包合物形成的驱动力被认为是范德华-伦敦色散力和疏水相互作用。此外，通过1H NMR光谱测量以及对Corey-Pauling-Koltun（CPK）模型的研究，对包合物的结构进行了讨论。
