Rothmund M, Stinner B, Arnold R
Department of Surgery, University Hospital, Marburg, Germany.
Eur J Surg Oncol. 1991 Apr;17(2):191-9.
Endocrine carcinomas of the pancreas are rare, but they should be treated aggressively because they threaten the patient's life by both malignant growth and hormone excess. Resection for cure should be attempted, but is hardly ever possible. Debulking should be performed primarily in hormone-active tumours so that symptoms can be controlled by subsequent medical treatment; this can be directed against tumour growth and/or hormone production, and it can reduce stomach acid secretion in the gastrinoma syndrome. Surgery should be undertaken whenever possible since the patient's life can be considerably prolonged in most cases. Palliative surgery can reduce the patient's symptoms that may be caused by excessive hormone production and/or obstruction of the bile duct or the duodenum.
胰腺内分泌癌很罕见，但因其恶性生长和激素分泌过多会威胁患者生命，所以应积极治疗。应尝试进行根治性切除，但几乎不可能实现。对于激素活性肿瘤，主要应进行减瘤手术，以便通过后续药物治疗控制症状；这种治疗可以针对肿瘤生长和/或激素产生，并且可以减少胃泌素瘤综合征中的胃酸分泌。只要有可能就应进行手术，因为在大多数情况下患者的生命可以得到显著延长。姑息性手术可以减轻患者因激素分泌过多和/或胆管或十二指肠梗阻而可能引起的症状。
