Saika T, Senba E, Noguchi K, Sato M, Yoshida S, Kubo T, Matsunaga T, Tohyama M
Department of Otolaryngology, Osaka University Medical School, Japan.
Brain Res Mol Brain Res. 1991 Jan;9(1-2):157-60. doi: 10.1016/0169-328x(91)90142-k.
We found that the level of nerve growth factor receptor (NGF-R) mRNA in facial motoneurons was increased after both facial nerve crushing and transection by means of in situ hybridization histochemistry. The increased level of NGF-R mRNA was maintained for at least 8 weeks after facial nerve transection, while facial nerve crushing caused only a transient increase. Thus, expression of NGF-R mRNA paralleled the axonal regeneration process. In addition, the increase of NGF-R mRNA with crushing was more pronounced than with transection from the 3rd to the 14th day after the insult.
