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[鼻窦腺癌:我们的经验]

[Sinonasal adenocarcinomas: our experience].

作者信息

Llorente José Luis, Núñez Faustino, Rodrigo Juan Pablo, Fernández León Ramón, Alvarez César, Hermsen Mario, Suárez Carlos

机构信息

Servicio de Otorrinolaringología y Unidad de Base de Cráneo, Instituto Universitario de Oncología del Principado de Asturias, Hospital Central Universitario de Asturias, Oviedo, Asturias, España.

出版信息

Acta Otorrinolaringol Esp. 2008 May;59(5):235-8. doi: 10.1016/s2173-5735(08)70229-1.

Abstract

INTRODUCTION AND OBJECTIVES

Sinonasal adenocarcinoma is a rare epithelial cancer of the nasal cavities and paranasal sinuses and exposure to sawdust particles is a strong aetiological factor.

MATERIAL AND METHOD

Seventy-nine patients (78 men and 1 woman) operated on between 1986 and 2002 were studied.

RESULTS

In 62 patients (78.5 %) there was a history of exposure to wood dust. The clinical factors presenting statistical significance in the multivariate analysis with prognosis were: the exclusive invasion of the middle concha (as good prognosis), recurrence and invasion of the dura mater (as bad prognosis). The actuarial survival rate was 36 % at 5 years falling to 28 % at 10 years.

CONCLUSIONS

Exposure to wood dust, even over a short period of time, must be considered as a high risk factor for the development of a sinonasal adenocarcinoma. This tumour must be ruled out in all patients suffering any type of sinonasal pathology.

摘要

引言与目的

鼻窦腺癌是鼻腔和鼻窦罕见的上皮性癌,接触木屑颗粒是一个重要的病因因素。

材料与方法

研究了1986年至2002年间接受手术的79例患者(78例男性和1例女性)。

结果

62例患者(78.5%)有接触木屑的病史。在多因素分析中,与预后具有统计学意义的临床因素为:仅侵犯中鼻甲(预后良好)、复发和侵犯硬脑膜(预后不良)。5年精算生存率为36%,10年降至28%。

结论

即使短时间接触木屑也必须被视为鼻窦腺癌发生的高危因素。所有患有任何类型鼻窦病变的患者都必须排除这种肿瘤。

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