Llorente José Luis, Núñez Faustino, Rodrigo Juan Pablo, Fernández León Ramón, Alvarez César, Hermsen Mario, Suárez Carlos
Servicio de Otorrinolaringología y Unidad de Base de Cráneo, Instituto Universitario de Oncología del Principado de Asturias, Hospital Central Universitario de Asturias, Oviedo, Asturias, España.
Acta Otorrinolaringol Esp. 2008 May;59(5):235-8. doi: 10.1016/s2173-5735(08)70229-1.
Sinonasal adenocarcinoma is a rare epithelial cancer of the nasal cavities and paranasal sinuses and exposure to sawdust particles is a strong aetiological factor.
Seventy-nine patients (78 men and 1 woman) operated on between 1986 and 2002 were studied.
In 62 patients (78.5 %) there was a history of exposure to wood dust. The clinical factors presenting statistical significance in the multivariate analysis with prognosis were: the exclusive invasion of the middle concha (as good prognosis), recurrence and invasion of the dura mater (as bad prognosis). The actuarial survival rate was 36 % at 5 years falling to 28 % at 10 years.
Exposure to wood dust, even over a short period of time, must be considered as a high risk factor for the development of a sinonasal adenocarcinoma. This tumour must be ruled out in all patients suffering any type of sinonasal pathology.
鼻窦腺癌是鼻腔和鼻窦罕见的上皮性癌,接触木屑颗粒是一个重要的病因因素。
研究了1986年至2002年间接受手术的79例患者(78例男性和1例女性)。
62例患者(78.5%)有接触木屑的病史。在多因素分析中,与预后具有统计学意义的临床因素为:仅侵犯中鼻甲(预后良好)、复发和侵犯硬脑膜(预后不良)。5年精算生存率为36%,10年降至28%。
即使短时间接触木屑也必须被视为鼻窦腺癌发生的高危因素。所有患有任何类型鼻窦病变的患者都必须排除这种肿瘤。