Driss M, Doghri R, Mrad K, Abbes I, Dhouib R, Sassi S, Ben Hamida N, Ben Romdhane K
Service d'anatomie et cytopathologie, institut Salah-Azaïz, Bab-Saadoun, boulevard 9-avril, 1006 Tunis, Tunisie.
Prog Urol. 2008 Apr;18(4):253-5. doi: 10.1016/j.purol.2008.03.004. Epub 2008 May 1.
Mucinous tubular and spindle cell carcinoma is a rare and newly described type of renal cell carcinoma (RCC) with a relatively indolent behaviour. We report a case of 53-year-old woman who had macroscopic hematuria and flank pain. A right radical nephrectomy was performed showing a well circumscribed tumour confined to the kidney and measuring 17cm. The histologic findings consisted of tightly packed, small, elongated tubules separated by pale mucinous stroma. The tumour cells were cuboidal to spindled with eosinophilic cytoplasm and lower nuclear grade. Tumour was immunoreactive for cytokeratin CK 7, CK19 and epithelial membrane antigen (EMA). The morphological and immunohistochemical features were consistent with mucinous tubular and spindle cell carcinoma of kidney.
黏液性小管状和梭形细胞癌是一种罕见的、新描述的肾细胞癌（RCC）类型，其行为相对惰性。我们报告一例53岁女性，她有肉眼血尿和侧腹疼痛。行右侧根治性肾切除术，显示肿瘤边界清楚，局限于肾脏，大小为17cm。组织学表现为紧密排列的小而细长的小管，被淡染的黏液性间质分隔。肿瘤细胞呈立方形至梭形，胞质嗜酸性，核分级较低。肿瘤对细胞角蛋白CK7、CK19和上皮膜抗原（EMA）呈免疫反应。形态学和免疫组化特征与肾黏液性小管状和梭形细胞癌一致。
