氨基嘧啶 IKK2 抑制剂的合成及构效关系
Synthesis and structure-activity relationship of aminopyrimidine IKK2 inhibitors.
作者信息
Bingham Alistair H, Davenport Richard J, Fosbeary Richard, Gowers Lewis, Knight Roland L, Lowe Christopher, Owen David A, Parry David M, Pitt Will R
机构信息
UCB, Granta Park, Great Abington, Cambridge CB21 6GS, UK.
出版信息
Bioorg Med Chem Lett. 2008 Jun 15;18(12):3622-7. doi: 10.1016/j.bmcl.2008.04.062. Epub 2008 Apr 29.
PMID:18501602
Abstract
The synthesis and structure-activity relationship of a novel series of aminopyrimidines are exemplified. Results of key compounds from within this series in the E-selectin reporter cell assay are also reported.
摘要
举例说明了一系列新型氨基嘧啶的合成及其构效关系。还报道了该系列中关键化合物在E-选择素报告基因细胞分析中的结果。
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