Brittain J E, Parise L V
Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel Hill, CB 7260, Chapel Hill, NC 27599, USA.
Transfus Clin Biol. 2008 Feb-Mar;15(1-2):19-22. doi: 10.1016/j.tracli.2008.03.013. Epub 2008 May 23.
The alpha4beta1 integrin is an adhesion receptor expressed on reticulocytes in sickle cell disease (SCD) and mediates the adhesion of these cells to sub-endothelial matrix proteins and the endothelium. In this review, we describe the mechanism of activation of the alpha4beta1 integrin on sickle reticulocytes and discuss novel roles for this integrin in SCD as a result of this activation. We also illustrate novel therapies in SCD that may target the integrin and alleviate vaso-occlusion.
α4β1整合素是一种在镰状细胞病（SCD）的网织红细胞上表达的黏附受体，介导这些细胞与内皮下基质蛋白和内皮的黏附。在本综述中，我们描述了镰状网织红细胞上α4β1整合素的激活机制，并讨论了这种激活导致该整合素在SCD中的新作用。我们还阐述了SCD中可能靶向该整合素并减轻血管闭塞的新疗法。
