Department of Epidemiology, Erasmus MC University Medical Center, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands.
Neurobiol Aging. 2010 Mar;31(3):378-86. doi: 10.1016/j.neurobiolaging.2008.04.008. Epub 2008 May 23.
We investigated in a population-based cohort study the association of global and lobar brain tissue volumes with specific cognitive domains and risk of dementia. Participants (n=490; 60-90 years) were non-demented at baseline (1995-1996). From baseline brain MRI-scans we obtained global and lobar volumes of CSF, GM, normal WM, white matter lesions and hippocampus. We performed neuropsychological testing at baseline to assess information processing speed, executive function, memory function and global cognitive function. Participants were followed for incident dementia until January 1, 2005. Larger volumes of CSF and WML were associated with worse performance on all neuropsychological tests, and an increased risk of dementia. Smaller WM volume was related to poorer information processing speed and executive function. In contrast, smaller GM volume was associated with worse memory function and increased risk of dementia. When investigating lobar GM volumes, we found that hippocampal volume and temporal GM volume were most strongly associated with risk of dementia, even in persons without objective and subjective cognitive deficits at baseline, followed by frontal and parietal GM volumes.
我们在一项基于人群的队列研究中调查了全脑和脑叶组织体积与特定认知领域和痴呆风险的关系。参与者（n=490；60-90 岁）在基线时（1995-1996 年）没有痴呆。从基线脑 MRI 扫描中，我们获得了 CSF、GM、正常 WM、白质病变和海马的全脑和脑叶体积。我们在基线时进行了神经心理学测试，以评估信息处理速度、执行功能、记忆功能和整体认知功能。参与者在随访期间发生痴呆，直至 2005 年 1 月 1 日。CSF 和 WML 体积越大，所有神经心理学测试的表现越差，痴呆风险越高。WM 体积越小，信息处理速度和执行功能越差。相比之下，GM 体积越小，记忆功能越差，痴呆风险越高。当研究脑叶 GM 体积时，我们发现海马体积和颞叶 GM 体积与痴呆风险的相关性最强，即使在基线时没有客观和主观认知缺陷的人群中也是如此，其次是额叶和顶叶 GM 体积。
